Basic Information
VIS ID
TVIS10005309
Fusion event
HBV-chr5 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1801
Orient
+
Integrated sequence
CATACTTCAAAGACTGTTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTG| |TTCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCA
Host Sequence
Chromosome
chr5
Cytoband
q32
Reference genome
GRCh37/hg19
Start
148816994/149437431 (Hg38)
End
148816994/149437431 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-10397/Upstream/6698; hsa-mir-103a-1/Downstream/295394;
Nearest TSS
ENST00000502646/Upstream/9142; ENST00000505810/Downstream/75689;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/79385, chr5-CpG: 93/Downstream/113255
Nearby gene
MIR143(-4595) ;
Nearest cancer related gene
MIR143(TSG, -4595) ;
Upstream sequence
TTCACTTTAAAGCCTAAGCATTGTATAATATTAAATAAGAGGAGGGGATGGGAGTGAAATGAGAATGGTATGAACAGAGGGAAATGAGAACACACCCAGA
Downstream sequence
TAAACGGGGCAGGGAGGGAAAGCAAATGTATTCCTCTTGTATACTTTTTTATATCTATATAAAGAAACCCAGGAAAAATACAAAAGGACCTAATAAAAGT
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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