Basic Information
VIS ID
TVIS10005316
Fusion event
HBV-chr6 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1820
Orient
+
Integrated sequence
GTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAAC| |TTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAA
Host Sequence
Chromosome
chr6
Cytoband
q16.1
Reference genome
GRCh37/hg19
Start
93609193/92899475 (Hg38)
End
93609193/92899475 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA6G
Nearest miRNA
hsa-mir-10398/Upstream/1377738; hsa-mir-1202/Downstream/5125056;
Nearest TSS
ENST00000381078/Upstream/175646; ENST00000452624/Downstream/170912;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/2287975, chr6-CpG: 92/Downstream/517079
Upstream sequence
aaagcaagtctggataaattttaaaaaatgaactcatatcaagcacactcttagatctcaatgtaatcaaaatataaataaatatcaacatctctcaaca
Downstream sequence
GttttttttttcttttttttctttttGAAACATAATTGTAGTCTCTCATTTACTACATAACAGTTTTCATTACACTTACCAAAATTGATTGTTAATGAGA
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
Curate