Basic Information
VIS ID
TVIS10005322
Fusion event
HBV-chr7 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1556
Orient
+
Integrated sequence
ACCCGTCTCGGGGCCGTTTGGGGCTCTACCGTCCCCTTCTTCATCTGCCGTTCCGGCCGACCACGGGGCGCACCTCTCTTTACGCGGTCTCCCCGTCTGT| |GCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCAGGTCTTGCCCAAGGTCTTACATA
Host Sequence
Chromosome
chr7
Cytoband
p22.1
Reference genome
GRCh37/hg19
Start
6667552/6627921 (Hg38)
End
6667552/6627921 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA7B
Nearest miRNA
hsa-mir-339/Upstream/916011; hsa-mir-10399/Downstream/439043;
Nearest TSS
ENST00000635602/Upstream/12304; ENST00000614588/Downstream/9401;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/4857, chr7-CpG: 130/Downstream/8902
Nearby gene
ZNF853(-3631) ; ZNF316(+9401) ;
Upstream sequence
tgggagatccacaccgtagcgtgggaacacaaatgcagcattacaaatgcagacatgacaccgaaaatataacacaccccattgctcatgTAACAAGCAC
Downstream sequence
ctccgtctctactaaaatacaaaaataattagccaggggtggtggtgcgtgcgtgtagtcccagctgcttgggaggctgaggcaggggaatcacttgaac
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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