VISDB Viral Integration Site DataBase

VIS ID

TVIS10005324

Fusion event

HBV-ZNRF2 integration

Validated

No

Detection method

PCR and Ultra-deep sequencing

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Start

1803

Orient

-

Integrated sequence

TACTTCAAAGACTGTTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTT| |CACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATG

Chromosome

chr7

Cytoband

p14.3

Reference genome

Start

End

30349321/30309705 (Hg38)

Orient

-

Location type

Intron

Target gene

miRNAs that regulate target gene

hsa-mir-103a-3p ; hsa-mir-4328 ; hsa-mir-6868-5p ; hsa-mir-3128 ; hsa-mir-4720-5p ; hsa-mir-4799-3p ; hsa-mir-5588-5p ; hsa-mir-503-5p ; hsa-mir-548c-3p ; hsa-mir-4524a-5p ; hsa-mir-4524b-5p ; hsa-mir-15a-5p ; hsa-mir-16-5p ; hsa-mir-15b-5p ; hsa-mir-195-5p ; hsa-mir-424-5p ; hsa-mir-486-5p ; hsa-mir-497-5p ; hsa-mir-4274 ; hsa-mir-4519 ; hsa-mir-6772-3p ; hsa-mir-6838-5p ; hsa-mir-5189-3p ; hsa-mir-8054 ; hsa-mir-548l ; hsa-mir-548k ; hsa-mir-548av-5p ; hsa-mir-559 ; hsa-mir-548y ; hsa-mir-548w ; hsa-mir-548o-5p ; hsa-mir-548j-5p ; hsa-mir-548i ; hsa-mir-548h-5p ; hsa-mir-548d-5p ; hsa-mir-548c-5p ; hsa-mir-548bb-5p ; hsa-mir-548b-5p ; hsa-mir-548ay-5p ; hsa-mir-548au-5p ; hsa-mir-548as-5p ; hsa-mir-548ar-5p ; hsa-mir-548aq-5p ; hsa-mir-548ap-5p ; hsa-mir-548am-5p ; hsa-mir-548ak ; hsa-mir-548ae-5p ; hsa-mir-548ad-5p ; hsa-mir-548ab ; hsa-mir-548a-5p ; hsa-mir-3191-5p ; hsa-mir-4470 ; hsa-mir-6824-3p ; hsa-mir-6764-3p ; hsa-mir-330-5p ; hsa-mir-326 ; hsa-mir-518c-5p ; hsa-mir-3675-3p ; hsa-mir-3973 ; hsa-mir-548al ; hsa-mir-129-5p ; hsa-mir-3680-3p ; hsa-mir-557 ; hsa-mir-507 ; hsa-mir-450b-5p ; hsa-mir-106a-3p ; hsa-mir-6722-5p ; hsa-mir-548x-5p ; hsa-mir-548g-5p ; hsa-mir-548f-5p ; hsa-mir-548aj-5p ; hsa-mir-1229-5p ; hsa-mir-4314 ; hsa-mir-3132 ; hsa-mir-197-5p ; hsa-mir-4448 ; hsa-mir-4268 ; hsa-mir-6776-5p ; hsa-mir-6861-5p ; hsa-mir-646 ; hsa-mir-548n ; hsa-mir-100-5p

Nearest miRNA

hsa-mir-1183/Upstream/19815; hsa-mir-10399/Downstream/2423276;

Nearest TSS

Nearest CpG islands

None/Target, chr7-CpG: 39/Upstream/23680, chr7-CpG: 68/Downstream/168666

Upstream sequence

tagctgccaacatttgacagttctaagattttctgtaaaaaccttgcttcccagcctctgcagaccagtcagaaggcctggctgcctggtctgcagcccc

Downstream sequence

ATTAAGCAGTACAGAAAGGTACCCGGTAATTTTTGTTTTGCATTGTTGTGATTCAGTTAAATGCTAAATTTTGCTGATCAGGAAAGTATAGATATGTAGC