Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10005328
Fusion event
HBV-ZNF277 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Start
1832
Orient
+
Integrated sequence
GGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCACCTCT| |GCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAATTTGGAGC
Host Sequence
Chromosome
chr7
Cytoband
q31.1
Reference genome
End
111895153/112255098 (Hg38)
Orient
+
Location type
Intron
Target gene
miRNAs that regulate target gene
hsa-mir-7151-3p ; hsa-mir-6807-5p ; hsa-mir-5095 ; hsa-mir-550a-5p ; hsa-mir-550a-3-5p ; hsa-mir-1271-3p ; hsa-mir-661 ; hsa-mir-3116 ; hsa-mir-1254 ; hsa-mir-6504-5p ; hsa-mir-3064-5p ; hsa-mir-4438 ; hsa-mir-6788-5p ; hsa-mir-7113-5p ; hsa-mir-30c-2-3p ; hsa-mir-4325 ; hsa-mir-30c-1-3p ; hsa-mir-7703 ; hsa-mir-500a-3p ; hsa-mir-6720-5p ; hsa-mir-6512-3p ; hsa-mir-8085 ; hsa-mir-6731-5p ; hsa-mir-6878-5p ; hsa-mir-767-5p ; hsa-mir-4524a-3p ; hsa-mir-3192-5p ; hsa-mir-766-3p ; hsa-mir-6849-3p ; hsa-mir-92b-3p ; hsa-mir-92a-3p ; hsa-mir-367-3p ; hsa-mir-363-3p ; hsa-mir-32-5p ; hsa-mir-25-3p ; hsa-mir-508-5p ; hsa-mir-129-5p ; hsa-mir-8055 ; hsa-mir-1273f ; hsa-mir-4708-5p ; hsa-mir-6088 ; hsa-mir-4770 ; hsa-mir-143-3p ; hsa-mir-8087 ; hsa-mir-7161-5p ; hsa-mir-548u ; hsa-mir-2355-3p ; hsa-mir-4646-3p ; hsa-mir-676-3p ; hsa-mir-501-5p ; hsa-mir-1224-5p ; hsa-mir-1294 ; hsa-mir-4316 ; hsa-mir-4751 ; hsa-mir-4677-3p ; hsa-mir-1197 ; hsa-mir-1290 ; hsa-mir-3167 ; hsa-mir-5004-3p ; hsa-mir-876-5p
Nearest miRNA
hsa-mir-10525/Upstream/9783567; hsa-mir-10399/Downstream/2398247;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/48266, chr7-CpG: 92/Downstream/136322
Upstream sequence
tcagtctcccaagcagctgggactacaggtgcccgccaccatgccctgctaatttttgtatttttagtagagacagggtttcaccatgttggccaggctt
Downstream sequence
TAATATATTTCAATTGTGTGGATGCTGACAAATATTCACCTTTTTGAAAGAAGTCTTTTAAATAGTGCTTTTTCTGTTTGTGGTTAATACTTCATTCTTT
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).