Basic Information
VIS ID
TVIS10005333
Fusion event
HBV-MIR2052HG integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1119
Orient
+
Integrated sequence
TGCCCCTTTTACACAATGTGGCTATCCTGCCTTGATGCCTTTATATGCATGTATACAATCTAAGCAGGCTTTCACTTTCTCGCCAACTTACAAGGCCTTT| |CTGTGTAAACAATATCTGCACCTTTACCCCGTTGCCCGGCAACGGTCAGGTCTCTGCCAAGTGTTTGCTGACGCAACCCCCACTGGATGGGGCTTGGCCA
Host Sequence
Chromosome
chr8
Cytoband
q21.12
Reference genome
GRCh37/hg19
Start
75600214/74687979 (Hg38)
End
75600214/74687979 (Hg38)
Orient
-
Location type
Intron
Target gene
MIR2052HG
Nearest miRNA
hsa-mir-124-1/Upstream/139362; hsa-mir-10400/Downstream/17714;
Nearest TSS
ENST00000518652/Upstream/54659; ENST00000521762/Downstream/14361;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/337170, chr8-CpG: 60/Downstream/296314
Upstream sequence
cataatgttctccgattccgtctacattgtcaccaatgacagaatttactttgtaaggctgaacagtattatttcattgtgtatatatactatacatttc
Downstream sequence
tcaattgtgcctcattaaagctgttaaaaaTTTTGGCTTCATTTGATAATGAGGGCTCTTCAAAAAGGCTGATCACTGCTTACAAGAGAGAACATACTTT
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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