Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10005343
Fusion event
HBV-CYSLTR2 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Start
1816
Orient
-
Integrated sequence
GTTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATG| |CAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGT
Host Sequence
Chromosome
chr13
Cytoband
q14.2
Reference genome
Start
End
49255822/48681686 (Hg38)
Orient
+
Location type
Intronic
Target gene
miRNAs that regulate target gene
hsa-mir-6873-3p ; hsa-mir-6868-3p ; hsa-mir-627-3p ; hsa-mir-1237-3p ; hsa-mir-6832-3p ; hsa-mir-500a-5p ; hsa-mir-6833-3p ; hsa-mir-4768-5p ; hsa-mir-1248 ; hsa-mir-6867-3p ; hsa-mir-5196-5p ; hsa-mir-4747-5p ; hsa-mir-107 ; hsa-mir-103a-3p ; hsa-mir-605-3p ; hsa-mir-4685-3p ; hsa-mir-4287 ; hsa-mir-7113-3p ; hsa-mir-4469 ; hsa-mir-3162-3p ; hsa-mir-9500 ; hsa-mir-3714
Nearest miRNA
hsa-mir-2276/Upstream/4485486; hsa-mir-1267/Downstream/1314729;
Nearest CpG islands
Upstream sequence
TCCATGGTGGACCACCTATTACTATTGTTTTTGGTGATCTCTTGTCTGTGGTCATGCCTGCCGGATTTCATGCCCTACCTTTGACAAGGAACTTACCCCA
Downstream sequence
GCATCTGTAACTGACAGTGTCCCTGAGGGCCTGCTACATCCCAGCAAGGGAGGAGTCCAGGGCTTGGTCCTGCCTCTCTCGAGCTGCCCTCTCCCTGCAA
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).