Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10005347
Fusion event
HBV-ADARB2 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Start
2997
Orient
-
Integrated sequence
TGTTCCCAATCCTCTGGGATTCTTTCCCGATCACCAGTTGGACCCTGCGTTCGGAGCCAACTCAAACAATCCAGATTGGGACTTCAACCCCAACAAGGAT| |CACTGGCCAGAGGCAAATCAGGTAGGAGCGGGAGCATTCGGGCCAGGGTTCACCCCACCACACGGCGGTCTTTTGGGGTGGAGCCCTCAGGCTCAGGGCA
Host Sequence
Chromosome
chr10
Cytoband
p15.3
Reference genome
Start
End
1413753/1371558 (Hg38)
Orient
+
Location type
Intron
Target gene
miRNAs that regulate target gene
hsa-mir-573 ; hsa-mir-3616-5p ; hsa-mir-4420 ; hsa-mir-181b-3p ; hsa-mir-181b-2-3p ; hsa-mir-144-5p ; hsa-mir-4795-5p ; hsa-mir-34c-3p ; hsa-mir-519c-3p ; hsa-mir-519b-3p ; hsa-mir-519a-3p ; hsa-mir-454-3p ; hsa-mir-301b-3p ; hsa-mir-130b-3p ; hsa-mir-130a-3p ; hsa-mir-4295 ; hsa-mir-301a-3p ; hsa-mir-3666 ; hsa-mir-548aw ; hsa-mir-1468-3p ; hsa-mir-548x-5p ; hsa-mir-548g-5p ; hsa-mir-548f-5p ; hsa-mir-548aj-5p ; hsa-mir-3117-5p ; hsa-mir-6776-3p ; hsa-mir-4753-5p ; hsa-mir-6768-3p ; hsa-mir-497-3p ; hsa-mir-2681-5p
Nearest miRNA
hsa-mir-5699/Upstream/729780; hsa-mir-107/Downstream/704461;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/7534, chr10-CpG: 30/Downstream/2223
Upstream sequence
caagcttctgcacagcaaaaaataaaataaagtaaaataaaaaagtaaacagacaacctacaaaatgggatgaaatatttgcaaattatgcctctgacaa
Downstream sequence
acggctaatatccggaatctgcatggaattcaaataacttagcaagaaaaaaccaaacaactccacaaaaaattgggcaaagggcatgaacagacatttc
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).