Basic Information
VIS ID
TVIS10005349
Fusion event
HBV-chr11 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Start
1818
Orient
+
Integrated sequence
TTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCA| |ACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTAT
Host Sequence
Chromosome
chr11
Cytoband
q24.1
Reference genome
End
122939933/123069225 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-let-7a-2/Upstream/916917; hsa-mir-3167/Downstream/312215;
Nearby gene
LOC101929289(-5994) ; CLMP(+2781) ;
Upstream sequence
tcgctactaaaaatacaaaaaattagccaggcgtggtggcaggcgcctgttgtcccaggtactcgggtggctgaggcaggagaatggcgtgaacccggga
Downstream sequence
ggcggagcttgcagtgagctgagattgtgccactgcactccagcctgggcgacaaagctagactcggtctcaaaataaaaataaaagtgaaaataaatgc
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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