DDIT3 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10005350
Fusion event
HBV-DDIT3 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
2039
Orient
-
Integrated sequence
GAGTTACTCTCTTTTTTGCCTTCTGACTTCTTTCCTTCTATTCGAGATCTCCTCGACACCGCCTCTGCTCTGTATCGGGAGGCCTTAGAGTCTCCGGAAC| |ATTGTTCACCTCACCATACAGCACTCAGGCAAGCTATTCTGTGTTGGGGTGAGTTGATGAATCTGGCCACCTGGGTGGGAAGTAATTTGGAAGACCCAGC
Host Sequence
Chromosome
chr12
Cytoband
q13.3
Reference genome
GRCh37/hg19
Start
57912930/57519147 (Hg38)
End
57912930/57519147 (Hg38)
Orient
+
Location type
DDIT3,intron MBD6,promoter
Target gene
DDIT3
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-96-5p ; hsa-mir-211-5p ; hsa-mir-633 ; hsa-mir-4645-3p ; hsa-mir-135a-3p ; hsa-mir-7845-5p ; hsa-mir-5692a
Nearest miRNA
hsa-mir-1228/Upstream/6397; hsa-let-7i/Downstream/16;
Nearest TSS
ENST00000382841/Upstream/3964; ENST00000552255/Downstream/1333;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/30895, chr12-CpG: 19/Downstream/877
Nearest cancer related gene
DDIT3(OG, No orient, 0)
Upstream sequence
attcactaccatctctaaattactgcagaaactttctgactgcagaaggtcttcccatttcttctcttgccacccctccgcaactctattcaccatacag
Downstream sequence
cagcctgagtgagccttttaaaacaggtcattcctctgctcaaaccctccaatgacttcctatttcatgtcatggaagtcactgaagggttttgagtgga
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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