Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10005352
Fusion event
HBV-NOS1 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Start
1590
Orient
+
Integrated sequence
CCTTCTTCATCTGCCGTTCCGGCCGACCACGGGGCGCACCTCTCTTTACGCGGTCTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCT| |TCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCAGGTCTTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGAC
Host Sequence
Chromosome
chr12
Cytoband
q24.22
Reference genome
End
117771876/117334071 (Hg38)
Orient
-
Location type
Intron
Target gene
miRNAs that regulate target gene
hsa-mir-146a-5p ; hsa-mir-1273f ; hsa-mir-143-3p ; hsa-mir-147a ; hsa-mir-3622a-5p ; hsa-mir-3911 ; hsa-mir-4269 ; hsa-mir-4708-5p ; hsa-mir-4710 ; hsa-mir-4770 ; hsa-mir-4792 ; hsa-mir-574-5p ; hsa-mir-6088 ; hsa-mir-644a ; hsa-mir-6715b-5p ; hsa-mir-6768-5p ; hsa-mir-6867-5p ; hsa-mir-7855-5p ; hsa-mir-8485
Nearest miRNA
hsa-let-7i/Upstream/905753; hsa-mir-1178/Downstream/2379563;
Nearest CpG islands
Upstream sequence
TCTTTAATGAAAGAAGCAACTGAAAGGCGACCTCTTGGGGAGGCAAGGCCCCCAAGCTGACTTCCTCCAGACTCTGGCTTGGGCCAGACCTTACTAAAGG
Downstream sequence
ACAGAGGCGGGAATTAGCCTTTGGTGTACTTTGCTTAAGGAAAAAAGAAAACAGAAATGAAGCAATTGGCAACAGCCCCTGGCCACTCTCAGCACGTTCT
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).