Basic Information
VIS ID
TVIS10005365
Fusion event
HBV-SELENOP integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
2833
Orient
-
Integrated sequence
AAACTAGGCATTATTTACATACTCTGTGGAAGGCTGGCATTCTATATAAGAGAGAAACTACACGCAGCGCTTCATTTTGTGGGTCACCATATTCTTGGGA| |ACAAGAGCTACAGCATGGGAGGTTGGTCTTCCAAACCTCGACAAGGCATGGGGACGAATCTTTCTGTTCCCAATCCTCTGGGATTCTTTCCCGATCACCA
Host Sequence
Chromosome
chr5
Cytoband
p12
Reference genome
GRCh37/hg19
Start
42810755/42810653 (Hg38)
End
42810755/42810653 (Hg38)
Orient
-
Location type
Intron
Target gene
SELENOP
Nearest miRNA
hsa-mir-10397/Upstream/4253092; hsa-mir-103a-1/Downstream/11140851;
Nearest TSS
ENST00000502646/Upstream/2248; ENST00000506791/Downstream/1236;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/385708, chr5-CpG: 47/Downstream/113459
Upstream sequence
ctaaatatccatcaacagatgattgaattaaaaaatgtgatatataaatatttatatatacatatatatacacacacgttgaatactatttagtcataag
Downstream sequence
ttcaccatgttggccaggctggtcttacactcctcacctcgtgatccgcctgccttggcctcccaaagtgctgggattacaagcgtgagccaccgcgtcc
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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