Fusion event
HBV-chrX integration
Detection method
PCR and Ultra-deep sequencing
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Integrated sequence
TCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAATTTGGAGCTTCTGTGGAGTTACTCTCTTTT| |TTGCCTTCTGACTTCTTTCCTTCTATTCGAGATCTCCTCGACACCGCCTCTGCTCTGTATCGGGAGGCCTTAGAGTCTCCGGAACATTGTTCACCTCACC
End
65965918/66746076 (Hg38)
Nearest miRNA
hsa-let-7f-2/Upstream/727097; hsa-mir-105-1/Downstream/3276781;
Upstream sequence
ACCTTGAGTAATCTTATATAAATCTAAGCCACATTCCATAAATGCTTCTTGTAGGTGCTTTTGTGTAATAAACGTATTTTCTTGGCTTTTATGAAGCTTA
Downstream sequence
GTGTTTATTGTGTCTAAAAATATCAGATTATAATTCTAATAAATGAAACTGACAAAAATACAAAGTACATGGGAAACAAAAGTGAAACTCTAGAAAATAA
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).