SPI1 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10005380
Fusion event
HBV-SPI1 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Start
2101
Orient
-
Integrated sequence
CTCTGCTCTGTATCGGGAGGCCTTAGAGTCTCCGGAACATTGTTCACCTCACCATACAGCACTCAGGCAAGCTATTCTGTGTTGGGGTGAGTTGATGAAT| |CTGGCCACCTGGGTGGGAAGTAATTTGGAAGACCCAGCATCCAGGGAATTAGTAGTCAGCTATGTCAATGTTAATATGGGCCTAAAAATCAGACAACTAT
Host Sequence
Chromosome
chr11
Cytoband
p11.2
Reference genome
End
47384375/47362824 (Hg38)
Orient
-
Location type
Intron
Target gene
Nearest miRNA
hsa-mir-129-2/Upstream/183087; hsa-let-7a-2/Downstream/38146;
Nearest cancer related gene
SPI1(OG, No orient, 0)
Upstream sequence
accaccatgcccagctaatttttgtatttttagtagagatggggtttcactatattggccaggctggtcttgatctcctgacctcgtgatctgcccacct
Downstream sequence
cagcctcccaaagtgctgggattacaggcttgagccactgcgcccagcTGAGACCCTGTCTCTTAACAAAAAAGTATTCAGTGTGCAGGGGGAGGGGCTT
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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