Fusion event
HBV-SPI1 integration
Detection method
PCR and Ultra-deep sequencing
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Integrated sequence
CTCTGCTCTGTATCGGGAGGCCTTAGAGTCTCCGGAACATTGTTCACCTCACCATACAGCACTCAGGCAAGCTATTCTGTGTTGGGGTGAGTTGATGAAT| |CTGGCCACCTGGGTGGGAAGTAATTTGGAAGACCCAGCATCCAGGGAATTAGTAGTCAGCTATGTCAATGTTAATATGGGCCTAAAAATCAGACAACTAT
End
47384375/47362824 (Hg38)
miRNAs that regulate target gene
Nearest miRNA
hsa-mir-129-2/Upstream/183087; hsa-let-7a-2/Downstream/38146;
Nearest cancer related gene
Upstream sequence
accaccatgcccagctaatttttgtatttttagtagagatggggtttcactatattggccaggctggtcttgatctcctgacctcgtgatctgcccacct
Downstream sequence
cagcctcccaaagtgctgggattacaggcttgagccactgcgcccagcTGAGACCCTGTCTCTTAACAAAAAAGTATTCAGTGTGCAGGGGGAGGGGCTT
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).