DOK5 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10005390
Fusion event
HBV-DOK5 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1817
Orient
+
Integrated sequence
TTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGC| |AACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTA
Host Sequence
Chromosome
chr20
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
53170161/54553622 (Hg38)
End
53170161/54553622 (Hg38)
Orient
+
Location type
Intron
Target gene
DOK5
Nearest miRNA
hsa-mir-103a-2/Upstream/485137; hsa-mir-1-1/Downstream/2767880;
Nearest TSS
ENST00000382410/Upstream/77904; ENST00000484860/Downstream/1311;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/77168, chr20-CpG: 165/Downstream/1449925
Upstream sequence
TGTCAAGCGACCTTTAAAGATGACCAGTCGAGTATAATAGTGCCACTCAGACATTTGCCATCAGTAACTATTATTATTAAATTATACTCATTTgctgggc
Downstream sequence
gcggtggctcacgtctgtaagcccagcactttgggaggccgaggcgggtggatcatgaggtgaggagtttgagtccagcctgaccaacatggtgaaaccc
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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