Basic Information
VIS ID
TVIS10005395
Fusion event
HBV-chr1 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1831
Orient
-
Integrated sequence
GGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCACCTC| |TGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAATTTGGAG
Host Sequence
Chromosome
chr1
Cytoband
p33
Reference genome
GRCh37/hg19
Start
47882784/47417112 (Hg38)
End
47882784/47417112 (Hg38)
Orient
-
Location type
Exon
Target gene
FOXE3 ; LINC01389
Nearest miRNA
hsa-mir-12136/Upstream/2871560; hsa-mir-101-1/Downstream/3642725;
Nearest TSS
ENST00000473358/Upstream/1040; ENST00000334793/Downstream/17529;
Nearest CpG islands
chr1-CpG: 129/Target, None/Upstream, None/Downstream
Upstream sequence
GCGCccccgagccgccctgctgcgccgcgcccgacgccgcagccgcagccttcccgccctgcgctgccgccgcctccccgccactctactcgcaggtccc
Downstream sequence
cgaccgcctggtactgcccgcgacgcgccccggccccggcccgctgcccgctgagcccctcctggccttggccGGGCCGGCAGCCGCTCTCGGCCCGCTC
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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