DCLRE1C _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10005398
Fusion event
HBV-DCLRE1C integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1808
Orient
+
Integrated sequence
CAAAGACTGTTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCA| |GCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACAT
Host Sequence
Chromosome
chr10
Cytoband
p13
Reference genome
GRCh37/hg19
Start
14948675/14906676 (Hg38)
End
14948675/14906676 (Hg38)
Orient
+
Location type
Intronic
Target gene
DCLRE1C
miRNAs that regulate target gene
hsa-mir-324-3p ; hsa-mir-1277-5p ; hsa-mir-3924 ; hsa-mir-190a-3p ; hsa-mir-5011-5p ; hsa-mir-410-3p ; hsa-mir-4495 ; hsa-mir-548n
Nearest miRNA
hsa-mir-1265/Upstream/470015; hsa-mir-107/Downstream/2938431;
Nearest TSS
ENST00000439456/Upstream/25176; ENST00000496225/Downstream/4646;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/26987, chr10-CpG: 64/Downstream/47005
Upstream sequence
TGTGTATACTAACTCTGAGTCTTGTTACCCTGGTTAGTCTGGTGGATCCAATACTTTTTGGTCGGATTGCCATGCAGCATCATGATAATGCATATCAAGT
Downstream sequence
GTTAGTTTAACTGATCTGCAAATTGTTTTAAGTGGTGTCTCTGCTTTTGCTTCCATAATCTATGAAATGTCACAATAACTAAGTGTTCCTGAATATCTGT
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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