Basic Information
VIS ID
TVIS10005399
Fusion event
HBV-chr10 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1800
Orient
+
Integrated sequence
GCATACTTCAAAGACTGTTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCT| |GTTCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGC
Host Sequence
Chromosome
chr10
Cytoband
q11.21
Reference genome
GRCh37/hg19
Start
43839914/43344466 (Hg38)
End
43839914/43344466 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10G
Target gene
LOC105378271 ; LOC107984226
Nearest miRNA
hsa-mir-1265/Upstream/346785; hsa-mir-107/Downstream/1819548;
Nearest TSS
ENST00000439456/Upstream/20801; ENST00000476166/Downstream/27176;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/1770, chr10-CpG: 38/Downstream/6344
Upstream sequence
TCAGTGGCACCCTGAGATCAGGCAATGGGCAGGCGTTTATAAATGTGCAGCTGCTCCAACCCGGCACCAGAATGGCTGTGGTGTGTGTGAGGCACTGCTC
Downstream sequence
CTTCCAAGAGCTTTCAGATTTGGGGTGAGGTGTACAGAGGAAGCAGCCACCTGTCACAGAAGACAGAGTAGTAAAGTTAAGAGAAAAGTGTGTccaggca
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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