Basic Information
VIS ID
TVIS10005400
Fusion event
HBV-chr11 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
2796
Orient
+
Integrated sequence
CCTTATTATCCTGAACATGCAGTTAATCATTACTTCAAAACTAGGCATTATTTACATACTCTGTGGAAGGCTGGCATTCTATATAAGAGAGAAACTACAC| |GCAGCGCTTCATTTTGTGGGTCACCATATTCTTGGGAACAAGAGCTACAGCATGGGAGGTTGGTCTTCCAAACCTCGACAAGGCATGGGGACGAATCTTT
Host Sequence
Chromosome
chr11
Cytoband
p15.5
Reference genome
GRCh37/hg19
Start
1676875/1655645 (Hg38)
End
1676875/1655645 (Hg38)
Orient
-
Location type
Intron
Nearest miRNA
hsa-mir-210/Upstream/398975; hsa-let-7a-2/Downstream/203819;
Nearest TSS
ENST00000527297/Upstream/25870; ENST00000538190/Downstream/7698;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/2651, chr11-CpG: 21/Downstream/38472
Nearby gene
FAM99A(+9954) ;
Upstream sequence
GTTGATGGGTGCCAGGGCTCCCGCATGCTGGACCAGCAGGGCACCCTGCAAGGTGGTGCCGCCTTGAGGCAGTGCCAGGAGGTGACGGCTCGCCCACACA
Downstream sequence
GGCTCCCGAACATCAGGGATACGCAGTAAAGACAACCTCATTCTAATGTTCTGTCTGTTTGGATAGGGACAAACACAGCCCAGATCTCAGCCCCCCGGCA
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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