Basic Information
VIS ID
TVIS10005401
Fusion event
HBV-LOC107987166 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1807
Orient
+
Integrated sequence
TCAAAGACTGTTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACC| |AGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACA
Host Sequence
Chromosome
chr11
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
116252994/116382277 (Hg38)
End
116252994/116382277 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA11G ; FRA11B
Target gene
LOC107987166
Nearest miRNA
hsa-mir-10392/Upstream/2932189; hsa-let-7a-2/Downstream/2261723;
Nearest TSS
ENST00000527297/Upstream/449420; ENST00000439483/Downstream/118353;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/621878, chr11-CpG: 30/Downstream/118265
Upstream sequence
cggaggtgtaagagacacccaaaaaaatccctttatttacggagtttatgctgtcacaggagaatagagataacaagcaaaatatatagtgcatcagaga
Downstream sequence
ggaataaatgcattggagaaaaataaagcaggaagagagaatgaggaacctgaaaggaaggttgctattttaaatagggtggtcagggcaggactttttg
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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