Basic Information
VIS ID
TVIS10005403
Fusion event
HBV-LINC02367 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1798
Orient
+
Integrated sequence
AGGCATACTTCAAAGACTGTTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGT| |CTGTTCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGG
Host Sequence
Chromosome
chr12
Cytoband
p13.31
Reference genome
GRCh37/hg19
Start
9545510/9392914 (Hg38)
End
9545510/9392914 (Hg38)
Orient
+
Location type
Intronic
Target gene
LINC02367
Nearest miRNA
hsa-mir-1244-3/Upstream/153363; hsa-let-7i/Downstream/2719038;
Nearest TSS
ENST00000382841/Upstream/25450; ENST00000487752/Downstream/214972;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/108856, chr12-CpG: 66/Downstream/54905
Upstream sequence
aacaaaacctccaagtttttgcctgtatcaataatttcttgctttttattcctgggtagtagtctcttatatggatatggtagaatttgttgagtctttc
Downstream sequence
accattgaaagatatttgggtggtttccagtttgaggctattttgaataaaacttttaagaacattgatgtacaggtttttgtgaacctgctttcattct
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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