Basic Information
VIS ID
TVIS10005413
Fusion event
HBV-AADACL2-AS1 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1956
Orient
-
Integrated sequence
CTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAATTTGGAGCTTCTGTGGAGTTACTCTCTTTTTT| |GCCTTCTGACTTCTTTCCTTCTATTCGAGATCTCCTCGACACCGCCTCTGCTCTGTATCGGGAGGCCTTAGAGTCTCCGGAACATTGTTCACCTCACCAT
Host Sequence
Chromosome
chr3
Cytoband
q25.1
Reference genome
GRCh37/hg19
Start
151621542/151903754 (Hg38)
End
151621542/151903754 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA3D
Target gene
AADACL2-AS1
Nearest miRNA
hsa-let-7g/Upstream/337759; hsa-mir-1224/Downstream/7378892;
Nearest TSS
ENST00000440867/Upstream/30111; ENST00000477171/Downstream/24414;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/816373, chr3-CpG: 92/Downstream/364784
Upstream sequence
aagtattttgagggaagatacttttaaaatcaaataaatatctctttcttcatcatattcaatttactcatttatttatttcttatttaggttccctgtt
Downstream sequence
tgcacccctacacttaaagaataaactatgtactcactgccacgaggattttctttttctctagcagctaaataagcactggccttgagataaacagtat
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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