Basic Information
VIS ID
TVIS10005416
Fusion event
HBV-chr5 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
2556
Orient
-
Integrated sequence
CCTTGGACTCATAAGGTGGGAAACTTTACTGGGCTTTATTCTTCTACTGTACCTGTCTTTAATCCTGAGTGGCAAACTCCCTCCTTTCCTAACATTCATT| |TACAGGAGGACATTATTAATAGATGTCAACAATATGTGGGCCCTCTTACAGTTAATGAAAAAAGGAGATTAAAATTAATTATGCCTGCTAGGTTCTATCC
Host Sequence
Chromosome
chr5
Cytoband
q31.2
Reference genome
GRCh37/hg19
Start
138669382/139333693 (Hg38)
End
138669382/139333693 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-10397/Upstream/1686044; hsa-mir-103a-1/Downstream/1229978;
Nearest TSS
ENST00000502646/Upstream/10947; ENST00000507415/Downstream/7894;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/39074, chr5-CpG: 87/Downstream/7951
Nearby gene
RN7SKP64(-328) ; PAIP2(+8139) ;
Nearest cancer related gene
PAIP2(TSG, +8139) ;
Upstream sequence
CTGGGAGGTCAGGACCCCGTGCCAGGATCACAGGGACCCCCCGAGGGGAGTCCAAGCTGCAGGAGGGAAGGACAGTTTGAGGGTGGGAGAGAGGAGGAGG
Downstream sequence
TTTGTAATTTTGTTGGGTATGTGGTAAGAAATTGCAAGGCATGTTAGTGGAATAGAACTACAACAGGAATTTGCCATTTTGCCTGGCCAAGTGGTTTGTA
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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