Fusion event
HBV-chr6 integration
Detection method
PCR and Ultra-deep sequencing
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Integrated sequence
AGTGCCAGCAGCGCCTCCTCCTGCCTCCACCAATCGGCAGTCAGGAAGACAGCCTACTCCCATCTCTCCACCTCTAAGAGACAGTCATCCTCAGGCCATG| |CAGTGGAA
End
164970001/164548968 (Hg38)
Nearest miRNA
hsa-mir-10398/Upstream/5784215; hsa-mir-1913/Downstream/1960386;
Upstream sequence
TTCCCTGCTGTAGTAGCCCAGGAGACTCTATGCTCCAGACTTTGTTGCTCCAAGATGAGGAAAGGCTTCCTGACAGAATCAGAccgtgatgtgagctgat
Downstream sequence
CAAACAAACAAAAAAAAgggatacatgtgcagaacgtgcagatttgttacataggtatacatgtgccatagtggtttgctgcacctactgacccatcctc
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).