DGKB _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10005423
Fusion event
HBV-DGKB integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
542
Orient
-
Integrated sequence
CTTCTGGACTACCAAGGTATGTTGCCCGTTTGTCCTCTACTTCCAGGAACATCAACTACCAGCACGGGACCATGCAAGACCTGCACGATTCCTGCTCAAG| |GAACCTCTATGTTTCCCTCTTGTTGCTGTACAAAACCTTCGGACGGAAACTGCACTTGTATTCCCATCCCATCATCCTGGGCTTTCGCAAGATTCCTATG
Host Sequence
Chromosome
chr7
Cytoband
p21.2
Reference genome
GRCh37/hg19
Start
14387856/14348231 (Hg38)
End
14387856/14348231 (Hg38)
Orient
-
Location type
Intron
Target gene
DGKB
miRNAs that regulate target gene
hsa-mir-3121-3p ; hsa-mir-495-3p ; hsa-mir-551b-5p ; hsa-mir-5688 ; hsa-mir-7-1-3p ; hsa-mir-7-2-3p ; hsa-mir-95-5p
Nearest miRNA
hsa-mir-339/Upstream/7281186; hsa-mir-10399/Downstream/3778989;
Nearest TSS
ENST00000635602/Upstream/79030; ENST00000412014/Downstream/370649;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/356643, chr7-CpG: 17/Downstream/2051266
Junction sequence
AC
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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