Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10005434
Fusion event
HBV-ZFHX4 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Start
2098
Orient
-
Integrated sequence
CGCCTCTGCTCTGTATCGGGAGGCCTTAGAGTCTCCGGAACATTGTTCACCTCACCATACAGCACTCAGGCAAGCTATTCTGTGTTGGGGTGAGTTGATG| |AATCTGGCCACCTGGGTGGGAAGTAATTTGGAAGACCCAGCATCCAGGGAATTAGTAGTCAGCTATGTCAATGTTAATATGGGCCTAAAAATCAGACAAC
Host Sequence
Chromosome
chr8
Cytoband
q21.13
Reference genome
Start
End
77659015/76746779 (Hg38)
Orient
+
Location type
Intron
Target gene
miRNAs that regulate target gene
hsa-mir-296-3p ; hsa-mir-128-3p ; hsa-mir-183-5p ; hsa-mir-92a-3p ; hsa-mir-19b-3p ; hsa-let-7b-5p ; hsa-mir-15a-5p ; hsa-mir-16-5p ; hsa-mir-200b-3p ; hsa-mir-15b-5p ; hsa-mir-195-5p ; hsa-mir-200c-3p ; hsa-mir-369-3p ; hsa-mir-424-5p ; hsa-mir-429 ; hsa-mir-409-3p ; hsa-mir-497-5p ; hsa-mir-545-3p ; hsa-mir-4524a-5p ; hsa-mir-4524b-5p ; hsa-mir-6838-5p ; hsa-mir-8084 ; hsa-mir-599 ; hsa-mir-3161 ; hsa-mir-5003-3p ; hsa-mir-646 ; hsa-mir-503-5p
Nearest miRNA
hsa-mir-124-1/Upstream/2041032; hsa-mir-10400/Downstream/219989;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/64154, chr8-CpG: 78/Downstream/253117
Upstream sequence
GCCTTTCCAGTCCACAAATTCAACTTATGAATAATTTGGCTCCCATCAACCCCGTAATCATAGATAAAAACATATACTTTGGAACCTAGTCTTGCAGAAT
Downstream sequence
AGAAGTAGAATCCATTGTAAAAGAAATAGGCAATTGTTCCACCTCTCCTTGGTACAGTCATTTCACCCTGCTGATGGTCCCTCTACTTGGGAGCCATTTT
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).