KIF26B _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10005439
Fusion event
HBV-KIF26B integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
2356
Orient
+
Integrated sequence
GGTGTCTTTTGGAGTGTGGATTCGCACTCCTCCCGCTTACAGACCACCAAATGCCCCTATCTTATCAACACTTCCGGAAACTACTGTTGTTAGACGACGA| |GGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATC
Host Sequence
Chromosome
chr1
Cytoband
q44
Reference genome
GRCh37/hg19
Start
245659641/245496339 (Hg38)
End
245659641/245496339 (Hg38)
Orient
-
Location type
Intron
Fragile sites / regions
FRA1I
Target gene
KIF26B
miRNAs that regulate target gene
hsa-mir-4530 ; hsa-mir-5685 ; hsa-mir-4690-3p ; hsa-mir-634 ; hsa-mir-629-3p ; hsa-mir-3944-3p ; hsa-mir-627-3p ; hsa-mir-6795-3p ; hsa-mir-4279 ; hsa-mir-501-5p ; hsa-mir-20a-5p
Nearest miRNA
hsa-mir-101-1/Upstream/2150084; hsa-mir-3124/Downstream/1705628;
Nearest TSS
ENST00000473358/Upstream/142661; ENST00000483253/Downstream/14663;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/160423, chr1-CpG: 17/Downstream/81352
Upstream sequence
acatgcagaaatgtggaaaaattaaagaatctggatgaggggcatatgggccattctatttttgtaaaatgttcagaaaataaatatagggcaaatataa
Downstream sequence
atgaacattgaccatataaaagaacaaaaatggggttttgtgggcactaaaatatatgtagcattaaatgcatgacaaaaacaatacaaaaagtgaaagg
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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