Basic Information
VIS ID
TVIS10005440
Fusion event
HBV-chr11 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1823
Orient
-
Integrated sequence
TAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTT| |TTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGA
Host Sequence
Chromosome
chr11
Cytoband
q14.2
Reference genome
GRCh37/hg19
Start
87553675/87842783 (Hg38)
End
87553675/87842783 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA11F
Target gene
LOC107984361 ; RAB38
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-let-7b-5p ; hsa-mir-30a-5p
Nearest miRNA
hsa-mir-10392/Upstream/1564385; hsa-let-7a-2/Downstream/333719;
Nearest TSS
ENST00000527297/Upstream/123372; ENST00000532849/Downstream/207323;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/804732, chr11-CpG: 45/Downstream/332292
Upstream sequence
CTATTTTAACCTGACTTTCCTGGAAAGACTACCTCAGAATACACAAGTGCACCTCACTAGCCAAAATAAATCCCCACCCCATGCGcacacatacacacat
Downstream sequence
gcatgcgcatgcacacacacacacacgcgcgcgcacacacacacacacacacacacacacacaAATCCCTTTTTATAAAAAATGTTTGAGAAACAAAAAA
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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