Basic Information
VIS ID
TVIS10005444
Fusion event
HBV-LOC105375974 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
2059
Orient
+
Integrated sequence
TTCTGACTTCTTTCCTTCTATTCGAGATCTCCTCGACACCGCCTCTGCTCTGTATCGGGAGGCCTTAGAGTCTCCGGAACATTGTTCACCTCACCATACA| |GCACTCAGGCAAGCTATTCTGTGTTGGGGTGAGTTGATGAATCTGGCCACCTGGGTGGGAAGTAATTTGGAAGACCCAGCATCCAGGGAATTAGTAGTCA
Host Sequence
Chromosome
chr9
Cytoband
p23
Reference genome
GRCh37/hg19
Start
11352778/11352778 (Hg38)
End
11352778/11352778 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC105375974
Nearest miRNA
hsa-mir-101-2/Upstream/5344874; hsa-let-7a-1/Downstream/7220528;
Nearest TSS
ENST00000422679/Upstream/76464; ENST00000473763/Downstream/806369;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/739445, chr9-CpG: 37/Downstream/265486
Upstream sequence
aaggtctacaagcccctggcacatggcagacaatcaataattgatcaTTTCCTTTGCATCTATAAATTTGTTCATTCACTTCTCATGTGGTTCTACTTTA
Downstream sequence
TAAATGCTCTCTCTCTCTCTTTTTAATGATTAAGGAAACTAGAAAATCACTATGTGTTAACAGAATCGTTTTACATTTGTAATATGGTAGTTCTGTGGGT
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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