Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10005460
Fusion event
HBV-AFF1 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Start
2059
Orient
-
Integrated sequence
TTCTGACTTCTTTCCTTCTATTCGAGATCTCCTCGACACCGCCTCTGCTCTGTATCGGGAGGCCTTAGAGTCTCCGGAACATTGTTCACCTCACCATACA| |GCACTCAGGCAAGCTATTCTGTGTTGGGGTGAGTTGATGAATCTGGCCACCTGGGTGGGAAGTAATTTGGAAGACCCAGCATCCAGGGAATTAGTAGTCA
Host Sequence
Chromosome
chr4
Cytoband
q22.1
Reference genome
Start
End
88021381/87100229 (Hg38)
Orient
-
Location type
Intron
Target gene
miRNAs that regulate target gene
hsa-mir-128b ; hsa-mir-877-5p ; hsa-mir-615-3p ; hsa-mir-19a-3p ; hsa-mir-19b-3p ; hsa-mir-142-3p ; hsa-mir-6073 ; hsa-mir-1914-5p ; hsa-mir-587 ; hsa-mir-17-5p ; hsa-mir-20a-5p ; hsa-mir-93-5p ; hsa-mir-106b-5p ; hsa-mir-20b-5p ; hsa-mir-519d-3p ; hsa-mir-885-3p ; hsa-mir-5197-5p ; hsa-mir-205-5p ; hsa-mir-1228-3p ; hsa-mir-519e-3p ; hsa-mir-515-3p ; hsa-mir-33b-3p ; hsa-mir-371a-3p ; hsa-mir-371b-3p ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-4279 ; hsa-mir-361-5p ; hsa-mir-889-3p ; hsa-mir-660-3p ; hsa-mir-5193 ; hsa-mir-1324 ; hsa-mir-2115-3p ; hsa-mir-3074-3p ; hsa-mir-5571-5p ; hsa-mir-7161-5p ; hsa-mir-548u ; hsa-mir-4744 ; hsa-mir-1273h-3p ; hsa-mir-143-5p ; hsa-mir-3944-5p ; hsa-mir-5093 ; hsa-mir-4480 ; hsa-mir-3166 ; hsa-mir-4771 ; hsa-mir-6790-3p ; hsa-mir-3691-3p ; hsa-mir-548an ; hsa-mir-31-5p ; hsa-mir-5684 ; hsa-mir-4511 ; hsa-mir-548b-3p ; hsa-mir-5692b ; hsa-mir-5692c
Nearest miRNA
hsa-mir-12113/Upstream/557677; hsa-mir-1243/Downstream/200266;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/92714, chr4-CpG: 109/Downstream/119461
Nearest cancer related gene
AFF1(OG, No orient, 0)
Upstream sequence
aaggatctcttgaggaagtaatatgagtatttcctttaaaaccttatcttgacaatttatgataatatcaagaagttccagaatgaatgtgggagagctg
Downstream sequence
TGTGGGATGCTGGGCTGTTAAACCAACAAGGTGTGGTCCACTTTCACAAGCATATTAACATTCCTGCCTCCTAGCAAGGGCCTCCAAGAACCTCCATAAC
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).