Basic Information
VIS ID
TVIS10005461
Fusion event
HBV-chrX integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
294
Orient
-
Integrated sequence
TGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCACAATACCACAGAGTCTAGACTCGTGGTGGACTTCTCTCAATTTTCTAGGGGGAGCACCCAC| |GTGTCCTGGCCAAAATTCGCAGTCCCCAACCTCCAATCACTCACCAACCTCTTGTCCTCCAATTTGTCCTGGCTATCGCTGGATGTGTCTGCGGCGTTTT
Host Sequence
Chromosome
chrX
Cytoband
q27.3
Reference genome
GRCh37/hg19
Start
142615781/143527948 (Hg38)
End
142615781/143527948 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRAXA
Nearest miRNA
hsa-let-7f-2/Upstream/2601717; hsa-mir-105-1/Downstream/2464802;
Nearest TSS
ENST00000429181/Upstream/10473; ENST00000423667/Downstream/106555;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/2350728, chrX-CpG: 130/Downstream/105646
Upstream sequence
GAGCTCACTGGACATGCTCACAAATACATGGCGTTTCAACTGAGCATAAACTTCCAATTTTATGTTAAATTTAAGCAATCTCCCTTTTCATAAAAGAAAA
Downstream sequence
atttcttgtaggacagggctggtgttgattaaatccctcagctcttgtttctctgggaccatctttatttctctttcatgtttgaaagatattttttcag
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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