Basic Information
VIS ID
TVIS10005468
Fusion event
HBV-chr12 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1001
Orient
+
Integrated sequence
GTACTTTACCACAGGAACATATTGTACGGAAACTCAAGCAATGTTTTCGAAAACTGCCTGTAAATAGACCTATTGATTGGAAAGTATGTCAAAGAATTGT| |GGGTCTTTTGGGCTTTGCTGCCCCTTTTACACAATGTGGCTATCCTGCCTTGATGCCTTTATATGCATGTATACAATCTAAGCAGGCTTTCACTTTCTCG
Host Sequence
Chromosome
chr12
Cytoband
q21.31
Reference genome
GRCh37/hg19
Start
84705014/84311235 (Hg38)
End
84705014/84311235 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA12B
Nearest miRNA
hsa-let-7i/Upstream/3152774; hsa-mir-1178/Downstream/2433833;
Nearest TSS
ENST00000382841/Upstream/26844; ENST00000393212/Downstream/556598;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/1623368, chr12-CpG: 17/Downstream/600186
Upstream sequence
aggttatgctctctttggcctgtaccgagctattcactgagtttgttagcatgctaaaacatttctgctcaacttgcaacttcaataacaggcatttctt
Downstream sequence
ttccttccttccttccttctttccttccttccttccttccttccttccttccttccttcctctctccctccctccctccctcccttccttcctttctttc
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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