Basic Information
VIS ID
TVIS10005472
Fusion event
HBV-LOC110806263 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Start
937
Orient
-
Integrated sequence
CCTAATAAAACCAAACGTTGGGGCTACTCCCTTAACTTCATGGGATATGTAATTGGAAGTTGGGGTACTTTACCACAGGAACATATTGTACGGAAACTCA| |AGCAATGTTTTCGAAAACTGCCTGTAAATAGACCTATTGATTGGAAAGTATGTCAAAGAATTGTGGGTCTTTTGGGCTTTGCTGCCCCTTTTACACAATG
Host Sequence
Chromosome
chr5
Cytoband
p15.33
Reference genome
End
1295451/1295336 (Hg38)
Orient
-
Location type
Promoter
Target gene
Nearest miRNA
hsa-mir-4635/Upstream/232362; hsa-mir-10397/Downstream/13974;
Nearest CpG islands
chr5-CpG: 485/Target, None/Upstream, None/Downstream
Upstream sequence
ttttcattaatttcactttcttaaaatttctcccttaattttgattttcacacagaagttagtcaggagaaagttgtttaattttcatctatttgtgtag
Downstream sequence
CCCGCCCGCGCGCCGCTCGCGCTCCCAGGGTGCAGGGACGCCAGCGAGGGCCCCAGCGGAGAGAGGTCGAATCGGCCTAGGCTGTGGGGTAACCCGAGGG
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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