Basic Information
VIS ID
TVIS10005475
Fusion event
HBV-LOC107985368 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
2559
Orient
-
Integrated sequence
TGGACTCATAAGGTGGGAAACTTTACTGGGCTTTATTCTTCTACTGTACCTGTCTTTAATCCTGAGTGGCAAACTCCCTCCTTTCCTAACATTCATTTAC| |AGGAGGACATTATTAATAGATGTCAACAATATGTGGGCCCTCTTACAGTTAATGAAAAAAGGAGATTAAAATTAATTATGCCTGCTAGGTTCTATCCTAA
Host Sequence
Chromosome
chr1
Cytoband
q43
Reference genome
GRCh37/hg19
Start
237137953/236974653 (Hg38)
End
237137953/236974653 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC107985368
Nearest miRNA
hsa-mir-101-1/Upstream/1121593; hsa-mir-3123/Downstream/496466;
Nearest TSS
ENST00000473358/Upstream/80312; ENST00000609253/Downstream/29765;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/178751, chr1-CpG: 169/Downstream/67173
Upstream sequence
aaacacctgaccagtactcctcaaagctgtcaagattggctgggcacagtgactctcacctgtaatcccagcactttgggaggccaaggtgggaggaaca
Downstream sequence
cttgagcccagaagttcaagaccagcttgggcaacatagtgagacactgtctctacaaataattagaaaattagctgagtgtggtagtgcacgcctgtgg
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
Curate