Basic Information
VIS ID
TVIS10005485
Fusion event
HBV-ADAMTS9-AS2 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1735
Orient
+
Integrated sequence
TCTTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAGGACTGGGA| |GGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCACCTCTGCC
Host Sequence
Chromosome
chr3
Cytoband
p14.1
Reference genome
GRCh37/hg19
Start
64676653/64690977 (Hg38)
End
64676653/64690977 (Hg38)
Orient
-
Location type
Promoter LOC100507098,intron
Target gene
ADAMTS9-AS2
Nearest miRNA
hsa-let-7g/Upstream/4073107; hsa-mir-12124/Downstream/2534487;
Nearest TSS
ENST00000440867/Upstream/2977; ENST00000481004/Downstream/483981;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/2696, chr3-CpG: 63/Downstream/665551
Nearest cancer related gene
ADAMTS9-AS2(TSG, No orient, 0)
Junction sequence
A
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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