Basic Information
VIS ID
TVIS10005488
Fusion event
HBV-PLPPR1 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1976
Orient
-
Integrated sequence
CTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAATTTGGAGCTTCTGTGGAGTTACTCTCTTTTTTGCCTTCTGACTTCTTTCCTT| |CTATTCGAGATCTCCTCGACACCGCCTCTGCTCTGTATCGGGAGGCCTTAGAGTCTCCGGAACATTGTTCACCTCACCATACAGCACTCAGGCAAGCTAT
Host Sequence
Chromosome
chr9
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
104028202/101265920 (Hg38)
End
104028202/101265920 (Hg38)
Orient
+
Location type
Intron
Target gene
PLPPR1
Nearest miRNA
hsa-let-7a-1/Upstream/3036703; hsa-mir-12126/Downstream/5335008;
Nearest TSS
ENST00000422679/Upstream/80885; ENST00000463206/Downstream/3882;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/236438, chr9-CpG: 49/Downstream/132651
Upstream sequence
GAGGTGGTGAGACTAAATCAGCAAATGAGAAGCAAAAAACATCCTAACAGCAATTATTCAACAGCCGCTAAAATTTGCAAAAGATGCCAGTATCTCCCAG
Downstream sequence
gggaggcagaggttgcagtgagccgagattgtgccattgcacaccagcctgggcgacagtgcgagacaccgcctcaaaaaaaaaaGGTCACAGGAGAATG
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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