Basic Information
VIS ID
TVIS10005497
Fusion event
HBV-ENTPD1-AS1 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1866
Orient
+
Integrated sequence
TTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCA| |AGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAATTTGGAGCTTCTGTGGAGTTACTCTCTTTTTTGCCTTCTGAC
Host Sequence
Chromosome
chr10
Cytoband
q24.1
Reference genome
GRCh37/hg19
Start
97840363/96080606 (Hg38)
End
97840363/96080606 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA10D
Target gene
ENTPD1-AS1
Nearest miRNA
hsa-mir-107/Upstream/16207; hsa-mir-1287/Downstream/748063;
Nearest TSS
ENST00000439456/Upstream/37023; ENST00000484770/Downstream/9549;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/36101, chr10-CpG: 42/Downstream/9205
Upstream sequence
aaggcaaagctctaaagacattcaaaagaatgaccacagaagtaaattatttaatactaggaaacactggtgtcagtgaagcccaagtaaaagaagattt
Downstream sequence
caagaagaaagtggataaactgtcacactggactgaacagaggtcaagtcagatagggtctgagaaatacccagtggatttagaaatgaagtggtagtta
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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