VISDB Viral Integration Site DataBase

VIS ID

TVIS10005498

Fusion event

HBV-KMT2A integration

Validated

No

Detection method

PCR and Ultra-deep sequencing

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Start

2376

Orient

-

Integrated sequence

TTCGCACTCCTCCCGCTTACAGACCACCAAATGCCCCTATCTTATCAACACTTCCGGAAACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAG| |AACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATCCCTTGGACTCATAAGGTGGG

Chromosome

chr11

Cytoband

q23.3

Reference genome

Start

End

118347841/118477126 (Hg38)

Orient

+

Location type

Intron

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-128b ; hsa-mir-335-5p ; hsa-mir-16-5p ; hsa-let-7d-5p ; hsa-mir-320b ; hsa-mir-1227-3p ; hsa-mir-484 ; hsa-mir-320a ; hsa-mir-193a-3p ; hsa-mir-17-5p ; hsa-mir-199a-3p ; hsa-mir-183-3p ; hsa-mir-199b-3p ; hsa-mir-142-3p ; hsa-mir-616-3p ; hsa-mir-2052 ; hsa-mir-3127-5p ; hsa-mir-3129-5p ; hsa-mir-3153 ; hsa-mir-4452 ; hsa-mir-4632-5p ; hsa-mir-4699-3p ; hsa-mir-4436b-3p ; hsa-mir-6733-5p ; hsa-mir-6735-5p ; hsa-mir-6739-5p ; hsa-mir-6879-5p ; hsa-mir-7843-5p ; hsa-mir-27a-3p ; hsa-mir-30a-3p ; hsa-mir-30d-3p ; hsa-mir-27b-3p ; hsa-mir-30e-3p ; hsa-mir-5681a ; hsa-mir-3918 ; hsa-mir-106a-3p ; hsa-mir-129-1-3p ; hsa-mir-129-2-3p ; hsa-mir-450b-5p ; hsa-mir-3121-5p ; hsa-mir-302c-3p ; hsa-mir-520f-3p ; hsa-mir-374a-5p ; hsa-mir-218-5p ; hsa-mir-636 ; hsa-mir-450a-1-3p ; hsa-mir-4668-5p ; hsa-mir-5189-3p ; hsa-mir-6895-5p ; hsa-mir-6832-3p ; hsa-mir-6809-3p ; hsa-mir-6833-3p ; hsa-mir-4768-5p ; hsa-mir-4753-3p ; hsa-mir-130b-5p ; hsa-mir-1250-3p ; hsa-mir-3942-3p ; hsa-mir-302c-5p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-3143 ; hsa-mir-4670-3p ; hsa-mir-6759-3p ; hsa-mir-6719-3p ; hsa-mir-4526 ; hsa-mir-3660 ; hsa-mir-6730-3p ; hsa-mir-624-3p ; hsa-mir-1293 ; hsa-mir-185-3p ; hsa-mir-30c-1-3p ; hsa-mir-30c-2-3p ; hsa-mir-3184-5p ; hsa-mir-363-5p ; hsa-mir-423-5p ; hsa-mir-4483 ; hsa-mir-4675 ; hsa-mir-4741 ; hsa-mir-541-3p ; hsa-mir-6085 ; hsa-mir-6134 ; hsa-mir-654-5p ; hsa-mir-671-5p ; hsa-mir-6716-5p ; hsa-mir-6731-5p ; hsa-mir-6743-3p ; hsa-mir-6745 ; hsa-mir-6748-5p ; hsa-mir-6756-5p ; hsa-mir-6766-5p ; hsa-mir-6769a-5p ; hsa-mir-6769b-5p ; hsa-mir-6788-5p ; hsa-mir-6813-5p ; hsa-mir-6871-5p ; hsa-mir-6873-5p ; hsa-mir-6878-5p ; hsa-mir-7974 ; hsa-mir-8085 ; hsa-mir-92a-2-5p ; hsa-mir-9500 ; hsa-mir-1178-5p ; hsa-mir-1180-3p ; hsa-mir-1301-3p ; hsa-mir-26a-1-3p ; hsa-mir-26a-2-3p ; hsa-mir-3926 ; hsa-mir-4660 ; hsa-mir-4778-5p ; hsa-mir-5047 ; hsa-mir-6850-3p

Nearest miRNA

hsa-mir-10392/Upstream/5027038; hsa-let-7a-2/Downstream/166874;

Nearest TSS

Nearest CpG islands

None/Target, chr11-CpG: 30/Upstream/40136, chr11-CpG: 106/Downstream/53394

Nearest cancer related gene

KMT2A(OG, No orient, 0)

Upstream sequence

TTGTTTGTTGATTATTCTGGGGATGCCCAGTAGGCTCTTCATAgttagtaggtcctctgaaaaacagatggcaagaggggattaaatacatgaggatttt

Downstream sequence

attagaagaaatgcctgagaaggaaaacggggaggtagccagggaaggctgggagagctgtcagactgtgttgcccatctcacccccatgaaggagcagg