Basic Information
VIS ID
TVIS10005504
Fusion event
HBV-chr13 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1822
Orient
+
Integrated sequence
TTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTT| |TTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAG
Host Sequence
Chromosome
chr13
Cytoband
q34
Reference genome
GRCh37/hg19
Start
112024726/111372379 (Hg38)
End
112024726/111372379 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-1267/Upstream/1031350; hsa-mir-4502/Downstream/1890541;
Nearest TSS
ENST00000623511/Upstream/51711; ENST00000607406/Downstream/215822;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/45627, chr13-CpG: 15/Downstream/29699
Upstream sequence
agacagaagtggggttggaacccagcactgtgcctgcggcgttcttggtttATCAGCTTTGTATGTTATGCATGGAGTTAATTCCATGAAAGATGAAGAT
Downstream sequence
GGACGCCCCATATCCACCAATTCTCATAATTCCTTTCCCATCTTCCCATCTGCATCGCTAACCACAGTGTCCGCACGTGCTGTCTCGCTGTTtctctgac
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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