Basic Information
VIS ID
TVIS10005505
Fusion event
HBV-L3HYPDH integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1827
Orient
+
Integrated sequence
GACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCA| |CCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAATTT
Host Sequence
Chromosome
chr14
Cytoband
q23.1
Reference genome
GRCh37/hg19
Start
59942983/59476265 (Hg38)
End
59942983/59476265 (Hg38)
Orient
-
Location type
Intron
Fragile sites / regions
FRA14B
Target gene
L3HYPDH
miRNAs that regulate target gene
hsa-mir-124-3p
Nearest miRNA
hsa-mir-208a/Upstream/4598072; hsa-mir-1185-1/Downstream/170697;
Nearest TSS
ENST00000550708/Upstream/154; ENST00000553156/Downstream/7420;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/10732, chr14-CpG: 117/Downstream/7477
Upstream sequence
TTCCATATAAAAAGGCAAGGTCTTCACTATCAGGATGATTAATTTTAAACTGCAAGTAACAAAAAAAGATCACATGCAAAATAAATATTTTGATTCAAAT
Downstream sequence
TTATAAATAATGCAGATGGGTCATTCTTAGACATAACTTTTTAATCCTTATCATTTTTAAAATACCTTTTTGGGCAACGTATACTAATTGCTAGAAATTA
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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