KCNS3 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10005509
Fusion event
HBV-KCNS3 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1618
Orient
-
Integrated sequence
ACGGGGCGCACCTCTCTTTACGCGGTCTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCAC| |CGTGAACGCCCACCAGGTCTTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGT
Host Sequence
Chromosome
chr2
Cytoband
p24.2
Reference genome
GRCh37/hg19
Start
18100325/17919058 (Hg38)
End
18100325/17919058 (Hg38)
Orient
-
Location type
Intron
Fragile sites / regions
FRA2C
Target gene
KCNS3
miRNAs that regulate target gene
hsa-mir-125b-5p ; hsa-mir-124-3p ; hsa-mir-215-5p ; hsa-mir-192-5p
Nearest miRNA
hsa-mir-3125/Upstream/5181614; hsa-mir-10b/Downstream/1429371;
Nearest TSS
ENST00000437798/Upstream/39675; ENST00000431697/Downstream/629146;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/39405, chr2-CpG: 69/Downstream/641144
Upstream sequence
CTCAGCTGGAGATGTGATGGAGTATTTACAGCAGGGCTAGGGGCCCCTCTTGTGGTAAAGTCCAGGTTTTTCCTGTTTCTGTTTGAAAAGCTATCATCTA
Downstream sequence
CGATTCTTTGCTTTTTACAAAGAGGACAGCTTTCTGGTTGTTTGGCTCACTAAATCACTCAGCCTTCTGAGCAGCTCTCTGCTTGGAGATGAGCTGTGTG
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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