Basic Information
VIS ID
TVIS10005516
Fusion event
HBV-LINC01811 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1819
Orient
-
Integrated sequence
TGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAA| |CTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATA
Host Sequence
Chromosome
chr3
Cytoband
p22.3
Reference genome
GRCh37/hg19
Start
34209919/34168427 (Hg38)
End
34209919/34168427 (Hg38)
Orient
+
Location type
Intronic
Target gene
LINC01811
Nearest miRNA
hsa-mir-12127/Upstream/1662038; hsa-let-7g/Downstream/1576049;
Nearest TSS
ENST00000440867/Upstream/9045; ENST00000455974/Downstream/34817;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/369248, chr3-CpG: 86/Downstream/1470590
Upstream sequence
TTTGAACATCAAGTGAATTTGTCTTTGAGAAATACAGATTGAAGCTTGCAGGTCCTGCATATCAAGTGTCATCCTTGGTTTGAAGAATCCAAATAGGGAC
Downstream sequence
actggactgttttagggaagtctatttccccacagtgtgaagcctTATCTTTGTTAATGAAGGGTTTGGGCAAATATATTCATTCATTAGAATATCACTG
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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