Basic Information
VIS ID
TVIS10005525
Fusion event
HBV-LINC02465 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1801
Orient
+
Integrated sequence
CATACTTCAAAGACTGTTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTG| |TTCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCA
Host Sequence
Chromosome
chr4
Cytoband
q28.2
Reference genome
GRCh37/hg19
Start
130861416/129940261 (Hg38)
End
130861416/129940261 (Hg38)
Orient
-
Location type
Intronic
Target gene
LINC02465
Nearest miRNA
hsa-mir-12113/Upstream/4432954; hsa-mir-1305/Downstream/13403199;
Nearest TSS
ENST00000502981/Upstream/102900; ENST00000508942/Downstream/435968;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/846517, chr4-CpG: 27/Downstream/1782931
Upstream sequence
AACCCATAATAATTAGCCCTAAATATTATTTTTGAAGCAATTCACAAGCTAAAATAATCTGTTAGTTAAGATCAGAAAATAAAACTCCCTCAAATCATGT
Downstream sequence
acatctattattattttggcttctttctaaaagtggtgagcggtcagactcttttgctggttacaTACGGATTTTCATTTTGGAGTTTCAGGCTCATTCA
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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