Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10005528
Fusion event
HBV-CTNND2 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Start
1550
Orient
+
Integrated sequence
CGGACGACCCGTCTCGGGGCCGTTTGGGGCTCTACCGTCCCCTTCTTCATCTGCCGTTCCGGCCGACCACGGGGCGCACCTCTCTTTACGCGGTCTCCCC| |GTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCAGGTCTTGCCCAAGGTCT
Host Sequence
Chromosome
chr5
Cytoband
p15.2
Reference genome
Start
End
11495790/11495678 (Hg38)
Orient
+
Location type
Intron
Target gene
Nearest miRNA
hsa-mir-10397/Upstream/1017533; hsa-mir-103a-1/Downstream/3330251;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/110269, chr5-CpG: 141/Downstream/407760
Nearest cancer related gene
CTNND2(OG, No orient, 0)
Upstream sequence
tttcattaatttcactttcttaaaatttctcccttaattttgattttcacacagaagttattcaggagaaagttgtttaattttcatctatttgtgtagt
Downstream sequence
TCTTCTTTCTCTTGAACTTCTGCATTCCCACCACTCCCTCTCTCCTGCCTCTGGCAGAACAAGGCTTGAAGTTCAGCTCTTAAGTGACTTTTGCAACAGA
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).