Basic Information
VIS ID
TVIS10005535
Fusion event
HBV-PANTR1 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1674
Orient
+
Integrated sequence
CCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCAGGTCTTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCT| |CAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACT
Host Sequence
Chromosome
chr2
Cytoband
q12.1
Reference genome
GRCh37/hg19
Start
105457560/104841102 (Hg38)
End
105457560/104841102 (Hg38)
Orient
-
Location type
Intron
Fragile sites / regions
FRA2S
Target gene
PANTR1
Nearest miRNA
hsa-mir-1285-2/Upstream/2408736; hsa-mir-10b/Downstream/4300388;
Nearest TSS
ENST00000437798/Upstream/83383; ENST00000361360/Downstream/14409;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/181620, chr2-CpG: 210/Downstream/1613
Junction sequence
TATAAATAAA
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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