Basic Information
VIS ID
TVIS10005554
Fusion event
HBV-chr16 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
2704
Orient
+
Integrated sequence
CAGTTAATGAAAAAAGGAGATTAAAATTAATTATGCCTGCTAGGTTCTATCCTAACCTTACCAAATATTTGCCCTTGGATAAAGGCATTAAACCTTATTA| |TCCTGAACATGCAGTTAATCATTACTTCAAAACTAGGCATTATTTACATACTCTGTGGAAGGCTGGCATTCTATATAAGAGAGAAACTACACGCAGCGCT
Host Sequence
Chromosome
chr16
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
46424293/46390381 (Hg38)
End
46424293/46390381 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-1225/Upstream/12226708; hsa-mir-11401/Downstream/3902235;
Nearest TSS
ENST00000527434/Upstream/10603494; ENST00000569239/Downstream/193872;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/10287668, chr16-CpG: 124/Downstream/37077
Upstream sequence
aatgcaatcacatggaatcatcacagaatggaatcgtacggaatcatcatcgaatggaattgaatggaatcatcaattggactcgaatggaaacatcaaa
Downstream sequence
tggaatcgattggaagtgtcgaatggactcgaatgaaatcatcgagtggaatcgaatggaatcatcgaaaggactcgaatcaaatcataaaatggactcg
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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