Basic Information
VIS ID
TVIS10005558
Fusion event
HBV-chr19 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
2497
Orient
-
Integrated sequence
AAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATCCCTTGGACTCATAAGGTGGGAAACTTTACTGGGCTTTATTC| |TTCTACTGTACCTGTCTTTAATCCTGAGTGGCAAACTCCCTCCTTTCCTAACATTCATTTACAGGAGGACATTATTAATAGATGTCAACAATATGTGGGC
Host Sequence
Chromosome
chr19
Cytoband
q13.11
Reference genome
GRCh37/hg19
Start
33771848/33280942 (Hg38)
End
33771848/33280942 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA19A
Nearest miRNA
hsa-mir-10395/Upstream/12881588; hsa-let-7e/Downstream/1841758;
Nearest TSS
ENST00000633603/Upstream/55092; ENST00000589932/Downstream/4797;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/44748, chr19-CpG: 302/Downstream/20213
Nearby gene
LOC111365153(-4701) ;
Upstream sequence
CATCCCGGCAAACCTGCAGGGCCCTTGATTGTAAGTCACCCCACTCACCCCGGGCTGCTTCTCACCACTGTTTCCTGTGCTGAAGTGGGAGTCCAGACCC
Downstream sequence
CCAAGAACCAGGATCCAGGGTCACTGATCACCAGGTCACCAGGGGCAGCTCCTACAGGCCTGGGGTCTGCCTGCGCTTCCTGTCGGGGATGGTGGCCCCT
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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