Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10005565
Fusion event
HBV-ZBTB8A integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Start
1818
Orient
+
Integrated sequence
TTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCA| |ACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTAT
Host Sequence
Chromosome
chr1
Cytoband
p35.1
Reference genome
Start
End
33005673/32540072 (Hg38)
Orient
-
Location type
Intron
Target gene
miRNAs that regulate target gene
hsa-mir-375 ; hsa-mir-130b-3p ; hsa-mir-103a-3p ; hsa-mir-21-5p ; hsa-mir-129-5p ; hsa-mir-8055 ; hsa-mir-1304-5p ; hsa-mir-4309 ; hsa-mir-3198 ; hsa-mir-6879-3p ; hsa-mir-6880-5p ; hsa-mir-4294 ; hsa-mir-1289 ; hsa-mir-6134 ; hsa-mir-7854-3p ; hsa-mir-215-3p ; hsa-mir-6773-3p ; hsa-mir-6812-3p ; hsa-mir-500b-3p ; hsa-mir-106a-3p ; hsa-mir-4430 ; hsa-mir-3652 ; hsa-mir-6722-5p ; hsa-mir-122-5p ; hsa-mir-504-3p ; hsa-mir-3135b ; hsa-mir-5685 ; hsa-mir-4690-3p ; hsa-mir-652-3p ; hsa-mir-454-3p ; hsa-mir-4295 ; hsa-mir-3666 ; hsa-mir-301b-3p ; hsa-mir-301a-3p ; hsa-mir-130a-3p ; hsa-mir-4520-2-3p ; hsa-mir-4520-3p ; hsa-mir-7703 ; hsa-mir-4793-3p ; hsa-mir-766-3p ; hsa-mir-4538 ; hsa-mir-4267 ; hsa-mir-4453 ; hsa-mir-508-5p ; hsa-mir-5093 ; hsa-mir-4708-3p ; hsa-mir-3188 ; hsa-mir-6884-5p ; hsa-mir-485-5p ; hsa-mir-2467-5p ; hsa-mir-3975 ; hsa-mir-2276-3p ; hsa-mir-1252-3p ; hsa-mir-4635 ; hsa-mir-6798-5p ; hsa-mir-6783-5p ; hsa-mir-10a-5p ; hsa-mir-10b-5p ; hsa-mir-1288-5p ; hsa-mir-3190-5p ; hsa-mir-339-5p ; hsa-mir-3926 ; hsa-mir-4433a-3p ; hsa-mir-4459 ; hsa-mir-4684-5p ; hsa-mir-4768-3p ; hsa-mir-4786-5p ; hsa-mir-548c-3p ; hsa-mir-548s ; hsa-mir-593-3p ; hsa-mir-6732-3p ; hsa-mir-6818-3p ; hsa-mir-6849-3p ; hsa-mir-6895-3p ; hsa-mir-143-5p ; hsa-mir-4534 ; hsa-mir-5698 ; hsa-mir-6499-3p ; hsa-mir-6514-5p ; hsa-mir-8082
Nearest miRNA
hsa-mir-12136/Upstream/453065; hsa-mir-101-1/Downstream/792321;
Nearest CpG islands
chr1-CpG: 106/Target, None/Upstream, None/Downstream
Upstream sequence
agggcagggcagggccggggccggAGTCTCTGCGGGCGCGGCCAGGGGCGCTGCCGGGGAACCTGGCTCCCAGGGCAGTAGCCCGAGTTTCTCGGTGCAG
Downstream sequence
CCTCCATCCTTGGTTTTATGTCAAGATGCGACATCTGGGCTTAGAACCGAGGGCGAACTCACCGCGCCTAACCAATGTTGAGCTCCCAACTATTTGCTTC
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).