Basic Information
VIS ID
TVIS10005568
Fusion event
HBV-LINC01707 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
986
Orient
-
Integrated sequence
TAATTGGAAGTTGGGGTACTTTACCACAGGAACATATTGTACGGAAACTCAAGCAATGTTTTCGAAAACTGCCTGTAAATAGACCTATTGATTGGAAAGT| |ATGTCAAAGAATTGTGGGTCTTTTGGGCTTTGCTGCCCCTTTTACACAATGTGGCTATCCTGCCTTGATGCCTTTATATGCATGTATACAATCTAAGCAG
Host Sequence
Chromosome
chr1
Cytoband
p31.2
Reference genome
GRCh37/hg19
Start
69602182/69136499 (Hg38)
End
69602182/69136499 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1C ; FRA1L
Target gene
LINC01707
Nearest miRNA
hsa-mir-101-1/Upstream/952889; hsa-mir-11399/Downstream/1931132;
Nearest TSS
ENST00000473358/Upstream/80601; ENST00000448001/Downstream/112924;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/639176, chr1-CpG: 131/Downstream/430785
Upstream sequence
AACATGACTATATTCTTTTCTTAGATTGTAAGATAACTGCAATAACTGTTGGTCAAAAGTTGTTTCTTCCTTAGTATCCATTTTAACTACAGATTTTTCT
Downstream sequence
TTTGGTTGAAAAAGAAGAATTATCTCTGAAGTAAGTACTGTCTATATGATATGGCAAGCATATATACATGGCAATCTCAGAATGCTTTAGTCAGGATTTT
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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