SBF2 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10005571
Fusion event
HBV-SBF2 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1779
Orient
+
Integrated sequence
ATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAG| |GCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTG
Host Sequence
Chromosome
chr11
Cytoband
p15.4
Reference genome
GRCh37/hg19
Start
10211777/10190230 (Hg38)
End
10211777/10190230 (Hg38)
Orient
-
Location type
Intron
Target gene
SBF2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-19b-3p ; hsa-mir-19a-3p
Nearest miRNA
hsa-mir-210/Upstream/1099851; hsa-let-7a-2/Downstream/318040;
Nearest TSS
ENST00000527297/Upstream/41038; ENST00000528544/Downstream/3727;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/431307, chr11-CpG: 76/Downstream/103502
Upstream sequence
acaagagtgaaactccgtctaaaaaaaaaaaaaaaCAGGAGCTAAGGTCAAAACAATACAATTTTGCTTTAATTCTTTAAGCTGTTTAGATGTCTCTGAT
Downstream sequence
CTAGCCAATAAAAATATTGTTCATATAATCAGGAATAGATTGTTAACCATAGAATGCCTCTGAAAAACAATTTTCTTTGAAATGCTGTCACTAAAATTAA
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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